Losartan: Should I take it every 24 or every 12 hours?

#Losartan is a very popular drug for the treatment of hypertension due to its proven efficacy and safety over decades, along with its low cost since generic versions are now available. It was the first of its kind, paving the way for many others in the years to come.

Losartan is a drug that blocks one of the most important mechanisms producing hypertension, the angiotensin II type 1 receptor, which is an essential part of the renin-angiotensin-aldosterone system. It is quickly absorbed when taken and is primarily metabolized by the liver. It is contraindicated in pregnancy, like all drugs of its class and ACE inhibitors, due to the risk of harm to the fetus.

But, can I take it once a day or is that insufficient?

Losartan and its main metabolite have a duration of less than 12 hours, which is why hypertensive patients often have an incomplete response when taking it once a day. Although each patient needs to be evaluated individually, we recommend administering it every 12 hours. So much so that long-duration pharmacological proposals have been developed due to this limitation of the drug.

💡 In summary, it is important to consult your cardiologist for a detailed clinical evaluation🩺 and to identify the best strategy for each patient.

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