馃拪 Why Enalapril is an Essential Drug for Diabetic Patients?

Here are some essential facts if you have diabetes.

6/3/20242 min read

Enalapril is an angiotensin-converting enzyme (ACE) inhibitor that has revolutionized the treatment of hypertension and other cardiovascular diseases such as coronary artery disease and heart failure. The history of enalapril began in the 1930s when Brazilian scientist Sergio Ferreira was studying the effects of the venom of the jararaca snake. Ferreira discovered that the venom contained a substance that could block the action of angiotensin II, a hormone that contributes to high blood pressure. This discovery marked the beginning of a long journey towards the development of an effective medication.

In the 1970s, scientists at the pharmaceutical company Merck, inspired by Ferreira's work, synthesized a synthetic analog of the compound called enalapril. Finally, in 1985, enalapril was approved by the US Food and Drug Administration (FDA) for the treatment of hypertension.

Why is it an essential drug for patients with diabetes?

It is a medication that has been shown to reduce death, heart attack, and stroke in high-risk patients such as diabetic patients (HOPE trial) and has also been shown to reduce the progression of kidney damage and kidney failure, a serious consequence of diabetes (micro HOPE trial).

馃┖ Of course, it is important for each patient to consult with their cardiologist to review in detail and obtain the best treatment for their cardiovascular condition.

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